Projects and Collaboration
I collaborate with Dr. Don Edwards, with whom I co-mentor PhD student Bryce Chung. We are developing computational techniques for model inference and parameter estimation for neuro-mechanical and electrophysioloical and cardiac models.
Here is a more detailed statement about my current research and future directions. My most recent work on informatic tools for "literate modeling" is documented on my blog, Transient Dynamic.
My current work is funded by an Army Research Office biomathematics STIR grant (2014-2015).
My work was supported by a 2008-2012 NSF grant from the Emerging Models and Technologies program of the Division of Computer and Communication Foundations. The title is "A Computational Framework for Inferring Self-Regulatory Properties from High-Dimensional Dynamic Models of Biological Systems".
I have also received internal GSU Research Initiation Grant, Brains and Behavior Area of Focus and Molecular Basis of Disease Area of Focus Seed Grant awards. I have current STEM teaching grant funding in projects with Drs. Iman Chahine (College of Ed.) and Mark Grinshpon (Dept. of Math and Stats) to study pre-calculus interventions in teaching calculus.
I work with the INCF, whose goals are described in this video:
- S. Şengül, R. Clewley, R. Bertram, J. Tabak. Determining the contributions of divisive and subtractive feedback in the Hodgkin-Huxley model, Journal of Computational Neuroscience, e-pub ahead of print, June 2014.
- J. Wojcik, J. Schwabedal, R. Clewley, A. Shilnikov. Key Bifurcations of Bursting Polyrhythms in Three-Cell Central Pattern Generators, PLoS ONE 9(4): e92918, 2014.
- A. Ogden, A. Cheng, P.C.G. Rida, V. Pannu, R. Osan, R. Clewley, R. Aneja. Quantitative multi- parametric evaluation of centrosome declustering drugs: Centrosome amplification, mitotic phenotype, cell cycle and death, Cell Death and Disease, 5(5): e1204, 2014.
- R. Clewley, Hybrid Models and Biological Model Reduction with PyDSTool, PLoS Computational Biology 8(8): e1002628, 2012. [Updated supplemental code is now available to work with the latest version of PyDSTool.]
- V. Pannu, P.C. Rida, A. Ogden, R. Clewley, A. Cheng, P. Karna, et al., Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach, Cell Death and Disease 3(7): e346, 2012.
- J. Wojcik, R. Clewley, A. Shilnikov, Order parameter for bursting polyrhythms in multifunctional central pattern generators, Physical Review E, Volume 83, No. 5, 2011. [preprint]
- R. Clewley, Inferring and quantifying the role of an intrinsic current in a mechanism for a half-center bursting oscillation: A dominant scale and hybrid dynamical systems analysis, Journal of Biological Physics, 37(3): 285-306, 2011. [preprint (with minor sign correction); PyDSTool code for this paper].
- R. Clewley, Encoding the Fine-Structured Mechanism of Action Potential Dynamics with Qualitative Motifs, Journal of Computational Neuroscience, 30:2, 391-408, 2011. [preprint; PyDSTool code for this paper]
- R. Clewley, C. Soto-Trevino, F. Nadim, Dominant ionic mechanisms explored in the transition between spiking and bursting using local low-dimensional reductions of a biophysically realistic model neuron, Journal of Computational Neuroscience, 26(1), 75-90, 2009. [preprint]
I share a computational lab with my collaborator Dr. Shilnikov in the Petit Science Center. We have a network of Macs, Linux machines and PCs, a machine with a Graphics Processing Unit for parallel computations, and interactive visualization tools.
June 2012: I gave this invited presentation during a workshop on epilepsy modeling at the Fields Institute in Toronto, entitled "Beyond Simulation and Big Data: How informatics and dynamics might merge to shape the future of modeling multi-scale diseases" (audio and slides). It also includes new work about the mechanistic understanding of Phase Response Curves (in preparation for publication).